In vitro secretion of cytokines and prostaglandin-E2by monocytes from lung cancer patients

In vitro secretion of cytokines and prostaglandin-E2by monocytes from lung cancer patients

Monocytes (MO) from cancer patients present functional abnormalities, such as an altered secretion of soluble factors. In the present study, our aim was to evaluate the levels of interleukin-1 β (IL-1 β), tumour necrosis factor-alpha (TNF- α) and prostaglandin-E2(PGE2) secreted in vitro by MO from l...

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Bibliographic Details
Published in:Respiratory medicine Vol. 95; no. 4; pp. 243 - 245
Main Authors: TREJO, Y.G., BORDENAVE, R.H., BEVIACQUA, M., RUMI, L.S.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-04-2001
Subjects:
IL-1 β
lung cancer
monocytes
PGE2
TNF- α
TNF- α
lung cancer
monocytes
PGE2
IL-1 β
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Summary:Monocytes (MO) from cancer patients present functional abnormalities, such as an altered secretion of soluble factors. In the present study, our aim was to evaluate the levels of interleukin-1 β (IL-1 β), tumour necrosis factor-alpha (TNF- α) and prostaglandin-E2(PGE2) secreted in vitro by MO from lung cancer patients (LCP), spontaneously or after stimulation with lipopolysaccharide (LPS). Results showed that cytokine secretion was higher for MO from LCP than for MO from healthy controls, while in the 25% of the patients analysed, an absence of response to LPS treatment was found.
ISSN:0954-6111
1532-3064
DOI:10.1053/rmed.2000.1007