Localization of the HumanRor1Gene (NTRKR1) to Chromosome 1p31–p32 by Fluorescencein SituHybridization and Somatic Cell Hybrid Analysis

Localization of the HumanRor1Gene (NTRKR1) to Chromosome 1p31–p32 by Fluorescencein SituHybridization and Somatic Cell Hybrid Analysis

Ror1is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed thatRor1is located on chromosome 1. We have mapped theRor1gene to chromosome 1p...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Vol. 41; no. 2; pp. 283 - 285
Main Authors: Reddy, Usha R., Phatak, Sagar, Allen, Cindy, Nycum, Lynn M., Sulman, Erik P., White, Peter S., Biegel, Jaclyn A.
Format: Journal Article
Language:English
Published: Elsevier Inc 15-04-1997
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Summary:Ror1is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed thatRor1is located on chromosome 1. We have mapped theRor1gene to chromosome 1p12–p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31–p32 by fluorescencein situhybridization using a PAC clone that contains theRor1gene.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1997.4653