Early predicting of preeclampsia in pregnant women after assisted reproductive technologies

• Published in: Акушерство, гинекология и репродукция Vol. 13; no. 4; pp. 305 - 312
• Main Authors: Pitskhelauri, E. G., Strizhakov, A. N., Bogacheva, N. A., Kuzmina, T. E., Fedyunina, I. A.
• Format: Journal Article
• Language: English; Russian
• Published: IRBIS LLC 16-01-2020
• Subjects: chronic hypercoagulation; genetic thrombophilia; granulocyte-macrophage colony-stimulating factor; preeclampsia; pregnancy
• ISSN: 2313-7347; 2500-3194
• DOI: 10.17749/2313-7347.2019.13.4.305-312

Aim:
to identify new prognostic criteria of potential preeclampsia (PE) in pregnant women after assisted reproductive technologies (ART) for timely PE prophylaxis.
Materials and methods.
A prospective study of 85 patients who entered the program of ART was conducted. All patients were examined for possible hemostatic abnormalities (genetic thrombophilia and chronic hypercoagulation) and also for granulocytemacrophage colony-stimulating factor (GM-CSF) in the serum during the most critical periods (4–6, 12–14, 22–24 и and 30–32 weeks) of the fetoplacental complex formation.
Results.
The lowest level of GM-CSF was observed in patients with hemostatic disorders. Thus, in pregnant women who later developed PE, there was a decrease in GM-CSF level below the physiological: in those diagnosed with genetic thrombophilia – by 79.4 %, and those with hypercoagulation – by 63.6 %.
Conclusion.
The determination of serum GM-CSF and identification of hemostatic abnormalities in pregnant women after ART has a prognostic importance for potential PE. This result is significant for the understanding of the pathogenesis of PE and also has a practical value: it allows the doctor to attribute the patient to a high risk group from the first trimester of her pregnancy and start preventive therapy rather early.