Outpatient treatment and quality of life of patients with interstitial cystitis and Hunners lesion: cohort cross-sectional study

• Published in: Urologii͡a︡ (Moscow, Russia : 1999) no. 1; p. 5
• Main Authors: Karasev A, E, Bresso T, I, Markova O, D, Kasyan G, R, Pushkar D, Yu
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-03-2024
• Subjects: Adult; Aged; Ambulatory Care; Cohort Studies; Cross-Sectional Studies; Cystitis, Interstitial - drug therapy; Cystitis, Interstitial - therapy; Female; Humans; Male; Middle Aged; Prospective Studies; Quality of Life; pentosan; bladder pain syndrome; Hunners lesion; interstitial cystitis
• ISSN: 1728-2985
• DOI: 10.18565/urology.2024.1.5-9

To assess the quality of life of patients with interstitial cystitis (IC) and to study effective options used to control symptoms on outpatient basis.
The results of a descriptive prospective cross-sectional cohort study are presented. The medical charts of patients who were treated in the City Clinical Hospital named after Spasokukotsky from 2021 to 2023 were analyzed. Eighty inpatient medical charts of various patients with a final diagnosis of IC with Hunner's lesion were identified. Only 53 patients were interviewed due to the inclusion/exclusion criteria. Respondents were asked to complete a survey consisting of 15 questions. The survey was carried out online for patients who did not require surgical treatment at the time of the study, and offline for patients admitted for repeated surgical treatment.
The average age of respondents was 59.011.1 years. 58% (31) of patients noted the presence of constant pain in the pelvic area during the day, while 85% (45) of patients reported pain outside the bladder area, in the urethra and perineum. The intensity of pain in the pelvic area was 4.9 (2.3-5.6) points. Higher pain scores 6.24 (5.8-9.0) were observed in 47% (25) of patients admitted for repeat surgical treatment. 62% (33) of patients had a titer of bacteria in a urine test above 104, while 51% (27) of patients experienced relief of symptoms after taking antibacterial drugs. For the treatment and symptomatic relief, the following are most often used: pentosan sodium polysulfate (26%, n=14), antibacterial drugs of the nitrofuran group (25%, n=13), amitriptyline (15%, n=8), non-steroidal anti-inflammatory drugs (11%, n=6) patients. 23% (12) of respondents received intravesical therapy. The time from the onset of symptoms to the final diagnosis was 48 (24-96) months.
Although infection is a criterion for excluding the diagnosis of IC, more than 62% of patients have positive urine culture. The results obtained indicate the need to improve existing approaches to the diagnosis of IC, as well as to develop treatment algorithms for painful bladder syndrome to control symptoms.