Evaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorder

• Published in: Neurochemical journal Vol. 18; no. 1; pp. 214 - 219
• Main Authors: Eser Sağaltıcı, Belli, Hasan, Kirankaya, Aysegul, Köse, Hüseyin, Ural, Cenk, Namlı, Mustafa Nuray, Demirci, Onur Okan, Gökçay, Hasan
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-03-2024
• Subjects: Biomedical and Life Sciences; Biomedicine; Clinical Neurochemistry; Neurosciences; OCD; arylesterase; dipeptidyl peptidase-IV; oxidative DNA damage; paraoxonase; oxidative stress
• ISSN: 1819-7124; 1819-7132
• DOI: 10.1134/S1819712424010173

Some findings have emerged from the field of oxidative stress in patients with psychiatric disorders. These date also state that oxidative balance and obsessive-compulsive disorder (OCD) are significantly related. Yet, researchers have not investigated oxidative stress, oxidative balance, and DNA damage together. We tested the levels of paraoxonase-1 (PON1), and arylesterase (ARE). We also tested the dipeptidyl peptidase-IV (DPP-IV), oxidative stress, and oxidative DNA damage. We enrolled 37 patients with OCD in the study. The diagnosis of OCD according to DSM-V criteria was established. Patients had not received treatment for at least 6 months. The controls were matched with the patients about sex, age, body mass index (BMI), and smoking. Clinicians used the sociodemographic information form. All subjects were evaluated with a semi-structured questionnaire. Serum PON1, ARE, DPP-IV, oxidative stress index (OSI), and 8‑hydroxideoxiguanosine (8-OHdG) calculations were conducted in the biochemical laboratory. PON1 and DPP-IV levels were not different between OCD patients and the control group (
P
> 0.05). An oxidative DNA damage marker 8-OHdG—and OSI were higher in the patient’s group (
p
< 0.05). But levels of ARE were significantly lower in OCD patients (
P
< 0.05). We found evidence that oxidative stress-induced parameters such as OSI, ARE, and 8-OHdG might be related to a specific pathologic state in patients with OCD. The findings may provide a rationale for treating the pathological processes.