Natural history of the TT virus infection through follow-up of TTV DNA-positive multiple-transfused patients

• Published in: Blood Vol. 95; no. 1; pp. 347 - 351
• Main Authors: LEFRERE, J.-J, ROUDOT-THORAVAL, F, LEFRERE, F, KANFER, A, MARIOTTI, M, LERABLE, J, THAUVIN, M, LEFEVRE, G, ROUGER, P, GIROT, R
• Format: Journal Article
• Language: English
• Published: Washington, DC The Americain Society of Hematology 2000
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase - blood; Anemia, Aplastic - blood; Anemia, Sickle Cell - therapy; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; beta-Thalassemia - therapy; Biological and medical sciences; Blood Donors; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Child; Child, Preschool; DNA Virus Infections - physiopathology; DNA Virus Infections - transmission; DNA Viruses - isolation & purification; DNA, Viral - blood; Female; Follow-Up Studies; Humans; Infant; Male; Medical sciences; Transfusion Reaction; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Infection; Human; Multiple; Transfusion; DNA; Viral disease; Complication; Case history; Blood
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V95.1.347

Little is known about the natural history and the pathogenicity of the TT virus (TTV). We present our findings of a cross-sectional study based on the TTV DNA screening of 173 multiple-transfused patients and a longitudinal study based on the follow-up of TTV DNA-positive patients. Overall, 48 patients (27.7%) tested positive for TTV DNA. The influence of the number of blood donor exposures on the prevalence of blood-borne viral infection indicates that TTV, hepatitis C virus (HCV), and an RNA virus known as GB virus C/hepatitis G virus (GBV-C/HGV) share a parenteral transmission, but that TTV, in contrast to the 2 other viruses, is also transmitted by at least another efficient means. The patients having a well-defined date of TTV infection were positive for TTV DNA during a mean period of 3.1 years. A chronic infection was observed in 31 cases (86%). TTV carriage appeared clinically benign in all patients. No clinical evidence of a disease potentially linked to the TTV infection was observed in patients with TTV DNA carriage over several years. The majority of TTV carriers had no biochemical evidence of liver disease. The prevalence of elevated serum alanine aminotransferase (ALT) level was higher in the TTV DNA-positive group, even in the absence of HCV infection, but the observed peaks of ALT level were most often transient and very mild. The prevalence of TTV DNA observed in blood recipients is consistent with that of TTV infection observed in blood donors. TTV infection frequently tends to persist. (Blood. 2000;95:347-351)