Clinical case of effective treatment of invasive mycosis caused by polyresistant strain of Candida auris

• Published in: Vestnik anesteziologii i reanimatologii Vol. 21; no. 4; pp. 85 - 91
• Main Authors: Selivanova, L. V., Balalaeva, M. A., Dymova, O. V., Chernova, E. V., Lukina, M. V., Krucenko, A. A., Petrenko, D. A., Dmitrieva, S. S., Eremenko, A. A.
• Format: Journal Article
• Language: English; Russian
• Published: New Terra Publishing House 27-08-2024
• Subjects: antifungal drugs; candida auris; candidemia; invasive candidiasis; mycosis
• ISSN: 2078-5658; 2541-8653
• DOI: 10.24884/2078-5658-2024-21-4-85-91

The objective was to demonstrate a clinical case of effective treatment of a patient with invasive mycosis caused by Candida auris with drug resistance to antifungal drugs by a combination of micafungin and amphotericin B lipid complex. Materials and methods . International databases such as MEDLINE, EMBASE, Web of Science and Scopus until 2023 were used for the analysis. Results . We have demonstrated the effective case of treatment of invasive candidiasis caused by the polyresistent pathogen Candida auris with the combination of micafungin and amphotericin B in the patient who underwent mitral valve replacement, which was complicated by acute aortic dissection, acute thrombosis of the superior mesenteric artery, septic shock and a number of other nosocomial infections. Conclusion . Due to the high resistance of Candida auris to all antifungal drugs currently existing in the world, the combination of several antifungal drugs is an advantage over monotherapy. However, given the lack of approved standards and guidelines for the treatment of patients with this infection, and insufficient clinical experience in the management of such patients, further search for effective treatment regimens for infections caused by Candida auris and the development of new antifungal agents that can overcome the resistance of this pathogen are necessary.