Expression of survivin, a novel apoptosis inhibitor and cell cycle regulatory protein, in human gliomas

• Published in: Chinese medical journal Vol. 117; no. 4; pp. 612 - 614
• Main Author: 焦保华 姚志刚 耿少梅 左书浩
• Format: Journal Article
• Language: English
• Published: China Department of Neurosurgery, Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China%Department of Neurosurgery, Third Hospital of Shijiazhuang, Shijiazhuang 050011, China%Department of Neurosurgery, First Hospital of Shijiazhuang, Shijiazhuang 050011, China 01-04-2004
• Subjects: Adolescent; Adult; Aged; Apoptosis; Cell Cycle; Cell Division; Child; Female; Glioma - chemistry; Glioma - pathology; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Male; Microtubule-Associated Proteins - analysis; Middle Aged; Neoplasm Proteins; Prognosis; Proto-Oncogene Proteins c-bcl-2 - analysis; 神经胶质瘤; 细胞凋亡; 细胞周期抑制素; 细胞周期调节蛋白; 肿瘤抑制; survivin; glioma; apoptosis
• ISSN: 0366-6999; 2542-5641

Recently, a novel anti-apoptosis gene, named survivin,was identified as a structurally unique member of the inhibitor of apoptosis protein (IAP) family. The gene is located on chromosome 17q25. Survivin is a 16. 5 kDa protein that is expressed in vivo in common human cancers, but not in normal adjacent tissue,^1 during the