18F- and 11C-labelling of quantum dots with n.c.a. [18F]fluoroethyltosylate and [11C]methyliodide: a feasibility study

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 283; no. 2; pp. 487 - 491
• Main Authors: Patt, M., Schildan, A., Habermann, B., Mishchenko, O., Patt, J. T., Sabri, O.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-02-2010
• Subjects: Chemistry; Chemistry and Materials Science; Diagnostic Radiology; Emittance; Fluorescence; Hadrons; Heavy Ions; Inorganic Chemistry; Labelling; Nuclear Chemistry; Nuclear Physics; Physical Chemistry; Positrons; Quantum dots; Size exclusion chromatography; Tomography; Size exclusion chromatography; Quantum dot; C; F; PET
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-009-0356-4

Quantum dots functionalized on the outer surface with either amino- or carboxyl functions were labelled with [
18
F]fluoroethyltosylate and [
11
C]methyliodide in order to use the positron emitter-labelled fluorescence agents for multimodality imaging techniques, i.e. fluorescence imaging and positron emission tomography.
18
F-Labelling of both compounds was realized with yields up to 5% as determined by size exclusion chromatography, which is twice as much as reported in literature before [
1
].
11
C-Labelling of amino- and carboxyl-QDs proceeded with good yields (up to 45 and 35%, respectively) under optimized reaction conditions. In general for both QD-types and both labelling agents the labelling yield increased with the amount of QDs used in the reaction as well as with reaction time and reaction temperature.