Hypertrophic Cardiomyopathy

• Published in: Heart, lung & circulation Vol. 13; pp. S48 - S55
• Main Author: Ivens, Emma
• Format: Journal Article
• Language: English
• Published: Australia Elsevier B.V 2004
• Subjects: Asymmetric septal hypertrophy; Ethanol (alcohol) septal ablation; Hypertrophic cardiomyopathy; Hypertrophic obstructive cardiomyopathy; Left ventricular hypertrophy; Myectomy; Myocyte disarray; Screening for hypertrophic cardiomyopathy; Asymmetric septal hypertrophy; Ethanol (alcohol) septal ablation; Left ventricular hypertrophy; Hypertrophic cardiomyopathy; Screening for hypertrophic cardiomyopathy; Myocyte disarray; Hypertrophic obstructive cardiomyopathy; Myectomy
• ISSN: 1443-9506; 1444-2892
• DOI: 10.1016/j.hlc.2004.09.021

Hypertrophic cardiomyopathy is a primary disorder of the myocardium characterised by disproportionate hypertrophy of the ventricular wall. It is the most common genetic cardiac disease with an incidence of 1 in 500 and it is diagnosed most commonly using transthoracic echocardiography.
This review article discusses: the diagnosis of hypertrophic cardiomyopathy; the differential diagnoses; the characteristic histological signs found at postmortem and/or myectomy and the clinical symptoms and signs.
Current recommendations for myectomy of first degree relatives, based on the ACC/ESC guidelines, are discussed as well as general management and then specific management for various subgroups and symptomatic patients.