Impact of Blood Loss Volume in Patients with Severe Mechanical Injury on the Cholesterol Atherogenicity Index

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 2; no. 6; pp. 44 - 49
• Main Authors: Shcherbakova, L. N., Bessekeyev, A. A., Molchanova, L. V.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20-12-2006
• Subjects: blood loss volume; lipoprotein spectrum; severe mechanical injury
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2006-6-44-49

Changed lipid metabolic parameters in parallel with a blood loss volume were studied in patients with severe mechanical injury, which were comparable by the APACHE II scale severity. The study indicated the elevated levels of atherogenic fractions with the increased blood loss volume that was significantly pronounced when it was 37 ml/kg or more. A rise of the cholesterol atherogenicity index also occurred with the higher blood loss volume. Changes in the lipoprotein spectrum with a blood loss volume of 25 ml/kg or more preserve within a rehabilitative month. In severe mechanical injury, normalization of the lipid spectrum promotes the use of perfluorane. It is concluded that blood loss predominantly affects the lipoprotein spectrum in severe mechanical injury.