Early Postischemic Cerebral Circulatory Disorders and Their Correction with Perftoran

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 2; no. 3; pp. 12 - 17
• Main Authors: Aleksandrin, V. V., Kozhura, V. L., Novoderzhkina, I. S., Moroz, V. V.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20-06-2006
• Subjects: cerebral ischemia; delayed hypoperfusion; no-reflow; perfluorane
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2006-3-12-17

Objective: to study the conditions and mechanism of postischemic no-reflow and delayed hypoperfusion and to correct them with perfluorane.Materials and methods: Both phenomena were reproduced by using a rat model of global cerebral ischemia.Results: no-reflow was shown to be caused by pial arteriolar collapse that occurred in ischemia and lasted during reperfusion. Delayed postischemic hypoperfusion was induced by increased pial arteriolar tone.Conclusion: Intraarterial injection of perfluorane alleviates the manifestation of both phenomena due to better oxygen supply to ischemic brain tissue and, probably, to calcium channel blockage.