REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS

• Published in: Medit͡s︡inskai͡a︡ immunologii͡a Vol. 11; no. 1; pp. 35 - 40
• Main Authors: Khasanova, R. R., Voronkova, O. V., Urazova, O. I., Novitsky, V. V., Strelis, A. K., Stambula, Yu. V., Kolosova, A. E., Serebryakova, V. A., Naslednikova, I. O., Kolokolova, O. V., Budkina, T. E., Pirogova, N. P.
• Format: Journal Article
• Language: English; Russian
• Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 14-07-2014
• Subjects: antigens; cytokines; lymphocytes; pumonary tuberculosis; reactivity
• ISSN: 1563-0625; 2313-741X
• DOI: 10.15789/1563-0625-2009-1-35-40

Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant.