Transporting Capacity of Albumin in Patients with Severe Mechanical Injury During Intravascular Laser Irradiation

• Published in: Obshchai͡a︡ reanimatologii͡a Vol. 1; no. 1; pp. 47 - 50
• Main Authors: Moroz, V. V., Kozhura, V. L., Kravchenko-Berezhnaya, N. R., Shcherbakova, L. N., Molchanova, L. V.
• Format: Journal Article
• Language: English
• Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 20-02-2005
• ISSN: 1813-9779; 2411-7110
• DOI: 10.15360/1813-9779-2005-1-47-50

The changes in the parameters of the transporting capacity of albumin, in some biochemical plasma parameters, and in the impact of low-energy laser irradiation on the studied parameters were examined in patients with severe mechanical injury in the early posttraumatic period. Thirty patients aged 17 to 70 years who had a health status of 78 to 98 scores by the APACHE-III scale were examined. The results indicated that as a consequence of prior hypoxia of mixed genesis and subsequent reperfusion and later on due to the development of endogenous intoxication, there were changes in the transporting capacity of albumin and in the de Ritis coefficient, a reduction in cholesterol concentrations, and increases in the levels of triglycerides and in the activity of gamma-glutamyl transpeptidase. Early quantum hemotherapy as a part of complex treatment makes it possible to prevent the progressive deterioration of the transporting capacity of plasma albumin, the critical reduction in the effective concentration of albumin, contributes to a more rapid recovery of the lowered levels of cholesterol and to a further increase in the activity of gamma-glutamyl transpeptidase, which is indicative of the recovered biosynthetic activity of the liver and its enhanced detoxifying activity.