Neurosyphilis in HIV-infected patients

• Published in: Vestnik dermatologij i venerologij Vol. 91; no. 2; pp. 49 - 57
• Main Authors: Krasnoselskikh, T. V., Sokolovskiy, E. V.
• Format: Journal Article
• Language: English
• Published: 24-04-2015
• ISSN: 0042-4609; 2313-6294
• DOI: 10.25208/0042-4609-2015-91-2-49-57

A review article is addressed the issue of the diagnosis and treatment of neurosyphilis that is developing against the background of HIV-infection. HIV-infected patients are at higher risk of neurologic, ocular and auricular manifestation of syphilis as well as treatment failures and relapses. Diagnosis of neurosyphilis in HIV-positive patients is complicated because both infections cause similar changes in the cerebrospinal fluid (CSF). The effectiveness of neurosyphilis treatment in patients with HIV co-infection is difficult to estimate, since the normalization of their CSF goes slower comparing to HIV-negatives. The increase in incidence of syphilis and HIV co-infection is anticipated in the coming years. This necessitates a comprehensive study of the problem and requires the development of new approaches to neurosyphilis diagnosis and treatment in co-infected patients.