Comparative study of thymidine kinase -1 and total antioxidant capacity in Iraqi children with platelet count disorder

• Published in: Ibn Al-Haitham Journal for Pure and Applied Sciences Vol. 31; no. 3; pp. 79 - 87
• Main Authors: Jabr, Manar Sattar, Abbas, Iman A. A.
• Format: Journal Article
• Language: English
• Published: Baghdad, Iraq University of Baghdad, College of Education for Pure Science / Ibn al-Haitham 22-11-2018; University of Baghdad
• Subjects: thrombocytopenia, thrombocytosis, thymidine kinase-1, total antioxidant capacity
• ISSN: 1609-4042; 2521-3407
• DOI: 10.30526/31.3.2017

This study aimed to find relationship between thymidine kinase-1 (TK-1) as tumor marker
and total antioxidant capacity (TAC) in Iraqi children patients with thrombocytopenia and
with thrombocytosis. The present study conducted 60 children patients (30 patients with
idiopathic thrombocytopenia purpura (ITP) and 30 patients with thrombocytosis caused by
leukemia) attending the Children Fever Hospital in the Medical City / Baghdad, and 30
healthy children as a control group. All study groups were with range ages (1-15) years, and
they were diagnosed by assay of platelet count, Prothrombin Time (PT), and partial
Thromboplastin Time (PTT). The results shown elevation in plasma TK-1 and TAC values in
children patients with thrombocytopenia and with thrombocytosis when compared with
control group, and there was no significant different in TK-1 level and a significant different
in TAC level in two patient’s groups. There was a highly significant positive correlation
between TK-1 and TAC levels in both Iraqi children patients with thrombocytopenia and with
thrombocytosis. The current study concluded that TK-1 may be a novel biomarker for platelet
count disorder disease and there was a probability of expose these patients for tumor diseases.