The adipose-derived Nerve Growth Factor is associated with abdominal obesity in prepubertal and pubertal children

• Published in: Proceedings of the Nutrition Society Vol. 79; no. OCE2
• Main Authors: Arizón, Pilar Argente, Rupérez, Azahara Iris, Aguilera, Concepción, Leis, Rosaura, Campos, Mercedes Gil, Gil, Ángel, Moreno, Luis Alberto, Bueno, Gloria
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 2020
• Subjects: Abdomen; Adipose tissue; Bioelectricity; Body fat; Body mass index; Body size; Body weight; Children; Conflicts of interest; Growth factors; Hepatocyte growth factor; Inflammation; Markers; Metabolic disorders; Metabolic syndrome; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Nerve growth factor; Obesity; Overweight; Physical growth; Regression analysis; Sex; Sympathetic nerves; Therapeutic applications
• ISSN: 0029-6651; 1475-2719
• DOI: 10.1017/S0029665120004589

IntroductionObesity is known to be associated with a low-grade inflammatory state. Most studies reporting inflammation in obesity have been done in pubertal children or adults or have focused only on the relation between body mass index (BMI) and the classical inflammatory markers. Nerve growth factor (NGF), monocyte chemoattractant protein–1 (MCP-1) and hepatocyte growth factor (HGF) are adipokines previously shown to be involved in the inflammatory context of obesity and metabolic syndrome but few studies have been conducted in children.ObjectiveTo evaluate the association between NGF, MCP-1, HGF with total and abdominal adiposity and in prepubertal and pubertal children.Methods889 children participated in a prospective obesity case-control study (50.2% males, 72% prepubertals, 27% overweight and 43% obesity), paired by age and sex. The relationship between total fat (assessed using the BMI, the sum of skinfolds thickness (SF) and fat mass index (FMI) from bioelectrical impedance analysis and waist circumference as a surrogate marker of abdominal obesity) and plasma concentrations of MCP-1, HGF, and NGF was studied in prepubertal and pubertal children.Linear regression analysis for prepubertal and pubertal children, adjusting for age, sex and center was used.ResultsNGF was associated with WC, with a stronger association in prepubertal than in pubertal children. MCP-1 was positively associated with WC, SF, FMI and BMI in pubertal children whereas HGF was positively associated with WC and BMI only in prepubertal children. The strongest associations were between WC and NGF (β 0.123 95%CI 0.133, 0.709; p < 0.001) in prepubertal children and WC and MCP-1 (β 0.123 95%CI 0.438, 2.035; p < 0.001) in pubertal children.DiscussionTotal and abdominal adiposity are related to plasma concentrations of adipokines in prepubertal and pubertal children with obesity. Adipokines such as NGF, HGF and MCP-1 have not been so well studied so far in obese children. Particularly, NGF was associated with WC and BMI in prepubertal children and with WC in pubertal children. The association between this neurotrophin, secreted by adipose tissue and involved in the development and survival of sympathetic neurons, with adiposity, especially in prepubertal children, could suggest an anti-inflammatory mechanism and thus be a potential therapeutic target.Conflict of interestNone