A Case Series of Myopericytoma: A Soft Tissue Neoplasm

Myopericytoma (MPC) is a rare benign mesenchymal neoplasm with perivascular myoid differentiation that most commonly arises in middle adulthood. The lesion generally involves the subcutaneous soft tissue of the lower extremities. Histologically, it is characterised by concentric perivascular prolife...

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Bibliographic Details
Published in:	National journal of laboratory medicine Vol. 13; no. 1; pp. 13 - 16
Main Authors:	Nupur Kaushik, Shikha Prakash, Garima Dundy, Juhi Singhal
Format:	Journal Article
Language:	English
Published:	JCDR Research and Publications Pvt. Ltd 01-01-2024
Subjects:	eosinophilic cytoplasm immunohistochemistry smooth muscle actin spindle myoid cells
Online Access:	Get full text
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Summary:	Myopericytoma (MPC) is a rare benign mesenchymal neoplasm with perivascular myoid differentiation that most commonly arises in middle adulthood. The lesion generally involves the subcutaneous soft tissue of the lower extremities. Histologically, it is characterised by concentric perivascular proliferation of spindled myoid cells with bland elongated nuclei associated with blood vessels. The present case series emphasises five cases of MPC in relatively younger-aged female patients. Fine Needle Aspiration Cytology (FNAC) was inconclusive in all five patients. Histopathological examination showed perivascular concentric proliferation of myoid tumour cells, which were ovoid, spindled, or round cells with abundant eosinophilic cytoplasm, and no nuclear atypia, hyperchromasia, or necrosis. Immunohistochemistry (IHC) was positive for Smooth Muscle Actin (SMA). Although MPC can be diagnosed through histopathological examination, IHC is required for confirmation.
ISSN:	2277-8551 2455-6882
DOI:	10.7860/NJLM/2024/60875.2817