Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

• Published in: Angewandte Chemie Vol. 135; no. 10
• Main Authors: Sousa‐Castillo, Ana, Mariño‐López, Andrea, Puértolas, Begoña, Correa‐Duarte, Miguel A.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01-03-2023
• Subjects: Aqueous Media; Biocompatibility; Biological Media; Biomedical materials; Bioorthogonal Catalysis; Catalysts; Chemical compounds; Chemistry; Copper; External stimuli; Fluorophores; Gold; Heterogeneous Catalysis; Medical imaging; Medical research; Nanoparticles; Palladium
• ISSN: 0044-8249; 1521-3757
• DOI: 10.1002/ange.202215427

Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool to perform novel biocompatible chemospecific reactions in living systems. Following the premise that they do not interfere with biological functions, bioorthogonal reactions are increasingly applied in biomedical research, particularly with respect to genetic encoding systems, fluorogenic reactions for bioimaging, and cancer therapy. This Minireview compiles recent advances in the use of heterogeneous catalysts for bioorthogonal reactions. The synthetic strategies of Pd‐, Au‐, and Cu‐based materials, their applicability in the activation of caged fluorophores and prodrugs, and the possibilities of using external stimuli to release therapeutic substances at a specific location in a diseased tissue are discussed. Finally, we highlight frontiers in the field, identifying challenges, and propose directions for future development in this emerging field.
Recent advances in the use of Pd‐, Au‐, and Cu‐based heterogeneous catalysts for bioorthogonal reactions are reviewed and discussed in detail. Synthetic strategies, applications, and external stimuli‐driven processes are compiled, setting the basis for future development in this field.