Osteocalcin: A link between bone homeostasis and energy metabolism

Abstract Research in animal models has demonstrated the role of osteocalcin, a bone formation marker, in regulation of energy metabolism. Those studies have led to a new concept of the bone acting as an endocrine organ by secreting osteocalcin, which acts by increasing insulin secretion, lowering pl...

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Bibliographic Details
Published in:	Endocrinologia y nutrición (English ed.) Vol. 60; no. 5; pp. 260 - 263
Main Authors:	García-Martín, Antonia, Reyes-García, Rebeca, Ávila-Rubio, Verónica, Muñoz-Torres, Manuel
Format:	Journal Article
Language:	English
Published:	Elsevier España, S.L.U 01-05-2013
Subjects:	Carbohydrate metabolism Endocrinology & Metabolism Lipid metabolism Metabolismo glucídico Metabolismo lipídico Osteocalcin Osteocalcina Carbohydrate metabolism Osteocalcin Osteocalcina Lipid metabolism Metabolismo lipídico Metabolismo glucídico
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Summary:	Abstract Research in animal models has demonstrated the role of osteocalcin, a bone formation marker, in regulation of energy metabolism. Those studies have led to a new concept of the bone acting as an endocrine organ by secreting osteocalcin, which acts by increasing insulin secretion, lowering plasma glucose, and increasing insulin sensitivity and energy expenditure. Results in humans have been conflicting. On the other hand, antiresorptive drugs used against osteoporosis decrease osteocalcin levels, while anabolic drugs increase osteocalcin levels. However, the effects of these therapies on energy metabolism have not been investigated.
ISSN:	2173-5093 2173-5093
DOI:	10.1016/j.endoen.2012.06.012