The functional effect of soybean extract and isolated isoflavone on myocardial infarction and ventricular dysfunction

• Published in: The Journal of nutritional biochemistry Vol. 23; no. 12; pp. 1740 - 1748
• Main Authors: Miguez, Ana C., Francisco, Julio C., Barberato, Sílvio H., Simeoni, Rossana, Précoma, Dalton, do Amaral, Vivian Ferreira, Rodrigues, Edson, Olandoski, Márcia, de Noronha, Lúcia, Greca, Fernando H., de Carvalho, Katherine Athayde Teixeira, Faria-Neto, José Rocha, Guarita-Souza, Luiz C.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-12-2012
• Subjects: Arginase; Functional foods; Isoflavone; Myocardial infarction; Soybean; Ventricular dysfunction; Isoflavone; Myocardial infarction; Ventricular dysfunction; Arginase; Soybean; Functional foods
• ISSN: 0955-2863; 1873-4847
• DOI: 10.1016/j.jnutbio.2011.05.017

Myocardial infarction is a public health problem. Functional food is an alternative treatment for cardiovascular diseases.
The objective was to analyze the functional and anatomopathological post-myocardial-infarction effects of soybean extract (SE) and isoflavone (IF).
Myocardial infarction was induced in adult Wistar rats. After 5 days, an echocardiogram was performed to determine heart rate (HR), ejection fraction (EF), systolic volume (LVESV) and diastolic volume (LVEDV). Animals with ventricular dysfunction (EF<45%) were selected for study. The animals were divided into three groups: control (n=14), SE (n=15) and IF (n=12). The IF group received 120 mg/kg/day isolated IF, and the SE group received 12.52 g/day. After 30 days, a new echocardiogram was performed. A histological exam was carried out to determine the collagen. Activity of biochemical markers [arginase, lactate dehydrogenase (LDH) and malate dehydrogenase] was measured.
The animals of the control, IF and SE groups showed a reduction in EF after the infarction (P=.432, P=.017 and P=.320, respectively). An increase of LVESV and LVEDV was observed in all groups (P=.009, P=.001 and P=.140; and P=.003, P=.008 and P=.205, respectively). A reduction of HR was found in the SE group (P=.020). There was a greater activity of LDH in the SE group. A smaller quantity of mature collagen was found in the region proximal to the myocardial infarction in the SE group.
A protective effect in the SE group was observed 30 days after the myocardial infarction.