Deletionof Mycobacterium tuberculosis Sigma Factor E Results inDelayed Time to Death with Bacterial Persistence in the Lungsof Aerosol-InfectedMice

• Published in: Infection and immunity Vol. 71; no. 12; pp. 7170 - 7172
• Main Authors: Ando, Masaru, Yoshimatsu, Tetsuyuki, Ko, Chiew, Converse, Paul J., Bishai, William R.
• Format: Journal Article
• Language: English
• Published: 01-12-2003
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.71.12.7170-7172.2003

The
stress-induced extracytoplasmic sigma factor E (SigE) of
Mycobacterium tuberculosis
shows increased expression after
heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as
well as after phagocytosis in macrophages. We report that deletion of
sigE
results in delayed lethality in mice without a
significant reduction of bacterial numbers in
lungs.