P-Glycoprotein and Its Role in Treatment Resistance

• Published in: Psikiyatride güncel yaklaşimlar Vol. 8; no. 1; pp. 1 - 31
• Main Authors: Gul, Isil, Eryilmaz, Gul, Karamustafalioglu, Oguz
• Format: Journal Article
• Language: English
• Published: Psikiyatride Güncel Yaklaşımlar 01-03-2016
• Subjects: blood and ndash;brain barrier; multipl drug resistance; P glycoprotein
• ISSN: 1309-0658
• DOI: 10.5455/cap.20150610111721

Polypharmacy which has often used to increase efficacy of treatment and to prevent resistance in psychiatry may lead to pharmacokinetic and pharmacodynamic drug interactions. One of the inten-sively studied topic in recent years to clarify the mechanism of drug interactions, in the pharmacoki-netic area is p-glycoprotein related drug-drug and drug-food interactions. The interactions of some drugs with p-glycoprotein which is a carrier protein, can lead to a decrease in the bioavailability of these drugs and reduction in passage through the blood-brain barrier. In this review, the role of p-glycoprotein on drug pharmacokinetics and bioavailability of psychiatric drugs are discussed. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(1): 19-31]