ESPGHAN Guidance on Coeliac Disease 2012
ABSTRACT The updated ESPGHAN guidance on coeliac disease recommends the use of common multiples of the upper limit of normal (ULN) for IgA tissue transglutaminase antibodies (TG2) when deciding which diagnostic pathway to follow. The current lack of standardisation between assays makes it difficult...
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| Published in: | Journal of pediatric gastroenterology and nutrition Vol. 55; no. 6; pp. 733 - 735 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-12-2012
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | ABSTRACT
The updated ESPGHAN guidance on coeliac disease recommends the use of common multiples of the upper limit of normal (ULN) for IgA tissue transglutaminase antibodies (TG2) when deciding which diagnostic pathway to follow. The current lack of standardisation between assays makes it difficult to harmonise results between centres as different performance characteristics are observed with each assay. This variability is shown in data from external quality assessment distributions. As a result, the updated guidance is too generalised for use with all the commercial TG2 kits and is therefore not translatable for use in all centres. |
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| Bibliography: | The raw data utilised in Appendix II of the guideline was provided by the UK NEQAS Immunology, Immunochemistry and Allergy Unit, of which W.E. is director and D.P. is deputy director. The other authors report no conflicts of interest. UK NEQAS was not formally asked to contribute or review the analysis, graphical presentation, and conclusions and was not formally part of the guideline development process. |
| ISSN: | 0277-2116 1536-4801 |
| DOI: | 10.1097/MPG.0b013e31826531f6 |