Colorectal Cancer with the BRAF V600E Mutation: Two Case Reports and Literature Review

Colorectal Cancer with the BRAF V600E Mutation: Two Case Reports and Literature Review

Colorectal cancer usually develops from stepwise, multiple mutations involving oncogenes and tumor suppressor genes. Mutations in the BRAF and RAS genes that dysregulate MAPK signaling are strongly associated with human malignancies. Colorectal cancer with the BRAF V600E mutation that causes cell pr...

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Bibliographic Details
Published in:International journal of biomedicine Vol. 14; no. 3; pp. 524 - 528
Main Authors: Nguyen Cuong Pham, Van Linh Ho, Victoria Ton-Nu, Minh Tri Ngo, Huu Son Nguyen
Format: Journal Article
Language:English
Published: International Medical Research and Development Corporation 10-09-2024
Subjects:
braf v600e mutation
ras genes
rectal cancer
Online Access:Get full text
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Summary:Colorectal cancer usually develops from stepwise, multiple mutations involving oncogenes and tumor suppressor genes. Mutations in the BRAF and RAS genes that dysregulate MAPK signaling are strongly associated with human malignancies. Colorectal cancer with the BRAF V600E mutation that causes cell proliferation without the need for growth factors has a worse prognosis than those without mutations. A BRAF V600E mutation was identified as an adverse prognostic factor for progression-free and overall survival. In this study, we analyze two cases of colorectal cancer with the BRAF V600E mutation and the literature data to investigate potential pathophysiologic mechanisms underlying metastatic colorectal cancer.
ISSN:2158-0510
2158-0529
DOI:10.21103/Article14(3)_CR1