Protective Role of Urtica Dioica on Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats

• Published in: Southern Clinics of Istanbul Eurasia Vol. 28; no. 1; pp. 1 - 7
• Main Author: Hakan Akdere
• Format: Journal Article
• Language: English
• Published: KARE Publishing 01-06-2017
• Subjects: ischemia-reperfusion; orchiectomy; testicular torsion/detorsion; urtica dioica
• ISSN: 2587-0998
• DOI: 10.14744/scie.2017.28482

INTRODUCTION[|]The aim of this study was to investigate the protective effect of Urtica dioica (UD) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.[¤]METHODS[|]Total of 32 male Wistar albino rats were divided into 4 groups (8 animals per group) as follows: Group 1, sham-operated control group; Group 2, I/R group; Group 3, UD (250 mg/kg for 14 days) group; and Group 4, I/R+UD (250 mg/kg for 14 days) group. Testicular torsion was created by rotating the right testis 720º clockwise. Ischemia period was 5 hours and orchidectomy was performed after 5 hours of detorsion.[¤]RESULTS[|]Biochemical analyses of testicular tissue revealed malondialdehyde level was significantly higher in I/R group compared with that of control group and UD group (p<0.01). Significant increase was also observed in I/R+UD group when compared with control group and UD group (p<0.05). Testis tissue glutathione level was not significantly different between groups (p>0.05). Additionally, UD-treated animals had better histopathological findings compared with I/R group.[¤]DISCUSSION AND CONCLUSION[|]There are very few studies of histopathological changes in UD treatment of testicular torsion/detorsion-induced I/R injury in rats. UD may be a promising approach for treatment of testicular torsion.[¤]