A New Murine Highly Localized High-Dose Muscle Radiation Model as a Tool to Develop Innovative Countermeasures to Treat Radio-Induced Muscular Lesions

A New Murine Highly Localized High-Dose Muscle Radiation Model as a Tool to Develop Innovative Countermeasures to Treat Radio-Induced Muscular Lesions

Acute localized irradiation accidents may evolve into a musculocutaneous radiation-induced syndrome that leaves a significant underlying muscle defect despite standard treatment. The identification of new therapeutic targets is, therefore, necessary to improve post-irradiation muscle repair. Thus, t...

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Bibliographic Details
Published in:Medical sciences forum Vol. 21; no. 1; p. 49
Main Authors: Nicolas Jullien, Emmanuelle Rota Graziosi, Michel Gauthier, Michel Drouet, Sabine Francois, Diane Riccobono
Format: Journal Article
Language:English
Published: MDPI AG 01-03-2023
Subjects:
cutaneous radiation syndrome
medical countermeasures
murine high-dose local irradiation model
muscle degeneration
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Summary:Acute localized irradiation accidents may evolve into a musculocutaneous radiation-induced syndrome that leaves a significant underlying muscle defect despite standard treatment. The identification of new therapeutic targets is, therefore, necessary to improve post-irradiation muscle repair. Thus, the validation of an in vivo model of radiation-induced muscle injury has been initiated in C57Bl/6J mice. In the model presented in this study, the high-dose ionizing radiation exposure is focused on gastrocnemius and soleus muscles, does not affect bones, and is a part of hindlimb vascularization. It aims at identifying original metabolic pathways specifically involved in muscle damage and evaluating innovative therapeutic strategies.
ISSN:2673-9992
DOI:10.3390/ECB2023-14280