Serum adipokines as biomarkers for the therapeutic monitoring of patients with inflammatory bowel diseases (IBDs) treated with infliximab: a systematic review and meta-analysis

• Published in: Revista colombiana de ciencias químico-farmacéuticas Vol. 51; no. 3
• Main Authors: Lima, William Gustavo, Alcântara Cândido, Patrícia, De Paula Sabino, Adriano, Nascimento Cardoso, Valbert, Antunes Fernandes, Simone Odília
• Format: Journal Article
• Language: English
• Published: Bogota Universidad Nacional de Colombia 2022
• Subjects: Antibodies; Biomarkers; Bowel disease; Etiology; Heterogeneity; Libraries; Meta-analysis; Monitoring; Monoclonal antibodies; Remission (Medicine); Software; Software reviews; Systematic review; Telemedicine
• ISSN: 0034-7418; 1909-6356
• DOI: 10.15446/rcciquifa.v51n3.107328

Introduction: Inflammatory bowel diseases (IBDs) are idiopathic inflammations of the colon, which can often undergo remission with the use of specific anti-TNF antibodies such as the infliximab. Although that the therapeutic monitoring can provide valuable insight into the possible etiolog y of unfavorable outcomes and allow for an appropriate management strateg y for these patients, currently none technique or biomarker have proved ideal for the evaluation of therapeutic benefices of anti-TNF antibodies in IBDs. Aim: To summarise current knowledge on the role of serum adipokines as potential biomarkers for the therapeutic monitoring of patients with IBDs under infliximab. Methods: A systematic review was carried out in the PubMed/MEDLINE, Cochrane Library, Scopus and Biblioteca Virtual em Saúde databases. Next, the meta-analysis was performed with the mean values of serum adipokine levels in patients with IBDs before and after the use of infliximab using the Review Manager (RevMan) ® 5.3 software. Results: Three studies that together included 58 patients diagnosed with IBDs and treated with infliximab at 5 mg/kg were selected. According to the quantitative analysis, serum leptin levels were significantly increased after the use of infliximab (p-value=0.01; Heterogeneity: I2=61%), which is correlated with the clinical remission of the disease. In addition, the circulating adiponectin (p-value=0.006; Heterogeneity: I2=0%) and resistin (p-value=0.009; Heterogeneity: I2=93%) concentrations were both reduced after the clinical remission of IBD with the use of infliximab. Conclusion: Serum leptin levels are significantly increased, while circulating adiponectin and resistin is reduced among IBD patients after the use of infliximab.