EFFECTS OF CANNABIDIOL, A CANNABIS SATIVA CONSTITUENT, ON ORAL WOUND HEALING

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 129; no. 1; pp. e166 - e167
• Main Authors: KLEIN, MARIANA, DE QUADROS DE BORTOLLI, JULIANE, BORGHETTI, RUCHIELI LOUREIRO, JACOBY, LETÍCIA SPINELLI, SALUM, FERNANDA GONÇALVES, CHERUBINI, KAREN, DE FIGUEIREDO, MARIA ANTONIA ZANCANARO
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-01-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.06.711

To evaluate the effect of cannabidiol (CBD) on the healing of rats’ oral wounds.
Traumatic ulcers were induced in 60 Wistar rats using a 5-mm biopsy punch on the midline of the ventral tongue. Animals received daily intraperitoneal (ip) injections of CBD at doses of 0 (control), 5 or 10 mg/kg. Rats were weighed daily and sacrificed after 3 and 7 days of treatment. Clinical (ulcer area and weight variation) and histopathologic (inflammation scores) analyses were performed. Data were analyzed statistically at the significance level of 5%.
CBD was unable to clinically influence the size of ulcerative lesions. However, treatment with CBD in both tested concentrations decreased inflammatory scores after 3 days post-wounding (P < .05) compared to control.
Five and 10 mg/kg CBD exerted promising anti-inflammatory effect in oral ulcerative lesions, not being enough to accelerate clinical wound healing at 3 and 7 days.