ANTIBIOTIC-RESISTANCE OF MICROBIAL FLORA ISOLATED FROM BIOPTATES MATERIAL FROM PATIENTS WITH ATHEROSCLEROSIS

• Published in: Ateroskleroz Vol. 14; no. 2; pp. 13 - 17
• Main Authors: D. M. Sharifullina, O. K. Pozdeev, R. M. Vasil’Eva, T. I. Yakovleva, R. N. Khayrullin
• Format: Journal Article
• Language: English; Russian
• Published: Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 01-06-2018
• Subjects: antibiotics sensitivity; atherosclerotic plaques; coagulase-negative staphylococci; propionibacterium
• ISSN: 2078-256X
• DOI: 10.15372/ATER20180202

The sensitivity of strains of microorganisms isolated from bioptates of atherosclerotic plaques to different antimicrobials was studied. For this study, the samples of atherosclerotic plaques from a group of patients that underwent elective carotid endarterectomy were used. Among 137 strains of coagulase-negative staphylococci 13.1 % of all isolates were methicillin-resistant, but all were sensitive to vancomycin, linezolid and moxifloxacin. Some strains of staphylococci possessed the resistance to erythromycin and tetracycline (16.3 %) and (13.9 %) respectively. The greatest resistance among coagulase-negative staphylococci to chloramphenicol (43.4 %) were identified. The high sensitivity of such bacteria to clindamycin, ciprofloxacin and gentamycin (92.6, 92.0 and 90.5 % respectively) were established. Among 197 isolates of Propionibacterium acnes all strains were highly sensitive to all antibiotics (amoxicillin, amoxicillin-clavulanic acid, benzylpenicillin, imipenem, clindamycin, piperacyllin, piperacyllin/tazobactam, ticarcillin, ticarcillin-clavulanic acid, chloramphenicol amd cefoxitin) which were tested. As exception was a metronidazole resistance to which bacteria are naturally refractory. The data obtained confirm that only small part of coagulase-negative staphylococci possessed the resistance to methicillin (13.1 %), but many among them demonstrated a high level of resistance to chloramphenicol. Between the strains of propionibacteria the acquired resistance to different antibacterials was not revealed.