CD4/CD8 double-negative mycosis fungoides: a review

Mycosis Fungoides (MF) stands as the predominant form of primary cutaneous T-cell lymphoma (CTCL). It manifests a diverse array of clinical, histological, and immunophenotypic variations, each bearing distinct prognostic implications. The typical immunophenotypic profile of mycosis fungoides involve...

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Bibliographic Details
Published in:	Dermatology reports
Main Authors:	Nabil Nagshabandi, Khalid, Shadid, Abdulrahman, Shadid, Asem, Almuhanna, Nouf K.
Format:	Journal Article
Language:	English
Published:	PAGEPress Publications 12-04-2024
Subjects:	CD4/CD8 negative cutaneous T-cell lymphomas double-negative Mycosis fungoides
Online Access:	Get full text
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Summary:	Mycosis Fungoides (MF) stands as the predominant form of primary cutaneous T-cell lymphoma (CTCL). It manifests a diverse array of clinical, histological, and immunophenotypic variations, each bearing distinct prognostic implications. The typical immunophenotypic profile of mycosis fungoides involves CD3+/CD4+/CD45RO+ memory T cells. Notably, the CD4-/CD8- double-negative variant of MF is a rare occurrence, observed in approximately 12% of early-stage cases and more prevalent in tumor-stage instances, often correlated with atypical clinical presentations. Despite its rarity, scant information is available about double-negative Mycosis Fungoides, with only a limited number of cases documented in the existing literature. This review aims to provide enhanced clarity, comprehension, and a detailed exploration of the spectrum encompassing double-negative mycosis fungoides.
ISSN:	2036-7392 2036-7406
DOI:	10.4081/dr.2024.9908