Role of pyroptosis in COVID-19

• Published in: "Qazaqstannyn͡g︡ klinikalyq medit͡s︡inasy" zhurnaly Vol. 20; no. 2; pp. 39 - 45
• Main Authors: Çelik, Mehmet, Ceylan, Mehmet Reşat, Karahan, Mahmut Alp, Koyuncu, İsmail, Dinçer, Nevin Güler, Alkan, Sevil
• Format: Journal Article
• Language: English
• Published: National Scientific Medical Center 21-04-2023
• Subjects: COVID-19; Interleukin-1β; Pyroptosis
• ISSN: 1812-2892; 2313-1519
• DOI: 10.23950/jcmk/13142

Aim: In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.
Material and Methods: This study was carried out with 58 participants, 28 (48.28%) of whom were diagnosis with COVID-19, and 30 (51.72%) of whom were healthy volunteers (control group).
Results: There were no statistically significant differences between the gasdermin-D, caspase-1, IL-1β, and NLRP3 levels as a result of all statistical comparisons performed. However, IL-1β values both during the discharge period and during the hospitalization period were considerably higher than those of the control group. At the discharge period, IL-1β values of the patients with severe COVID-19 category had higher than moderate patients, and the patients with moderate than the patients with mild patients.
Conclusion: It was observed that IL-1β, which is one of the cytokines released as a result of cell death in the pyroptosis mechanism, was higher in the COVID-19 patients in both the hospitalization and discharge periods compared to the control group. Although not statistically significant these results could support the relationship between pyroptosis and COVID-19.