Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats

• Published in: Inönü Üniversitesi Turgut Özal Tıp Merkezi dergisi Vol. 26; no. 9; pp. 1787 - 1791
• Main Authors: Pınar,Neslihan, Özcan,Oğuzhan, Doğan,Esin, Çakırca,Gökhan
• Format: Journal Article
• Language: English
• Published: Turgut Özal Tıp Merkezi Dergisi 01-09-2019
• Subjects: Sağlık Hizmetleri; Tıp; Türkiye; Malatya; gentamicin; Oxidative stress; antioxidant; nephrotoxicity; dexpanthenol
• ISSN: 1300-1744; 1300-1774
• DOI: 10.5455/annalsmedres.2019.07.435

Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing
a panel of biochemical and histopathologic parameters.
Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5
cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and
Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days.
Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress
index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px)
activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI
and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group.
Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp
group.
Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicity.