Different response to vitamin D supplementation of PVCs from RVOT and non-outflow tract RV regions

• Published in: European heart journal Vol. 42; no. Supplement_1
• Main Authors: Cismaru, G, Tomoaia, R, Minciuna, I, Lazea, C, Cainap, S.S, Fringu, F, Gurzau, D, Rosu, R, Gusetu, G, Puiu, M, Caloian, B, Comsa, D.H, Pop, D, Zdrenghea, D
• Format: Journal Article
• Language: English
• Published: 12-10-2021
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehab724.0661

Abstract
Background
Recent publications have shown that premature ventricular contractions (PVCs)_ from the right ventricular outflow tract (RVOT) have a good response to vitamin D supplementation in patients that have a vitamin D deficiency.
Purpose
The present study aimed to compare the response to vitamin D supplementation of of 2 types of PVCs: from RVOT and from other RV areas outside RVOT
Methods
Our study included 16 patients from the Outpatient Clinic of the Rehabilitation Hospital, of whom all had vitamin D deficiency. Four patients had high PVC burden with an RV morphology other than RVOT and were matched 1:3 for age and sex with 12 patients with high PVC burden and RVOT morphology.
Results
Mean age was 26 years in both group and 33% were females. The mean 25-OH vitamin D value was 17.7±2.9 ng/ml in the non RVOT group and 21.6±5.3 ng/ml in the RVOT group. After 3±1.7 month of treatment with 2000–5000 U/day, 25 OH vitamin D increased to. 31.1±3.2. in the non-RVOT group and to 35.9±5.1 in the RVOT group. After treatment PVC burden decreased from 19956±2618 to 19399±3015 (NS) in the non-RVOT group and from 21057±9594 to 4249±2835 (p=0.0001) in the RVOT group.
Conclusions
After 3 months of vitamin D supplementation in patients with high burden PVC and vitamin D deficiency, the burden decreased significantly by more than 75% in the RVOT morphology group but not in the non- RVOT morphology group.
Funding Acknowledgement
Type of funding sources: None. PVC burden in the non RVOT groupPVC burden in the RVOT group