Determination of the minimum alveolar concentration of isoflurane in donkeys
To determine the minimum alveolar concentration (MAC) of isoflurane in donkeys and characterize recovery from anesthesia. 7 healthy castrated male adult donkeys. Anesthesia was induced with propofol and maintained under mechanical ventilation with 1.3% isoflurane end-tidal concentration (ETiso). The...
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Published in: | American journal of veterinary research Vol. 83; no. 6 |
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Main Authors: | , , , |
Format: | Journal Article |
Language: | English |
Published: |
United States
08-05-2022
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Online Access: | Get full text |
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Summary: | To determine the minimum alveolar concentration (MAC) of isoflurane in donkeys and characterize recovery from anesthesia.
7 healthy castrated male adult donkeys.
Anesthesia was induced with propofol and maintained under mechanical ventilation with 1.3% isoflurane end-tidal concentration (ETiso). The MAC of isoflurane was determined after a 60-minute propofol washout period using the bracketing method. A continuous noxious electrical stimulation was applied to the oral mucosa for 1 minute or until the donkey moved. The ETiso was increased or decreased by 10% depending on the response, and MAC was defined as the average of 2 ETiso values allowing and preventing movement in response to stimulation. Arterial blood gases were measured during anesthesia and the recovery period. Unassisted recovery was timed, and a quality score was assigned from 1 (very poor) to 5 (excellent).
The mean dose of propofol required for induction was 3.0 ± 0.6 mg/kg. The MAC of isoflurane was 1.44 ± 0.13%. One donkey was excluded from the study because it was still responsive when stimulated at ETiso of 2.8%. Immediately after extubation, the median (range) partial pressure of oxygen in the arterial blood was 63 (minimum to maximum, 46 to 72) mm Hg and 3 donkeys were hypoxemic (partial pressure of arterial oxygen < 60 mm Hg). The median time to standing was 13 (7 to 38) minutes, while the recovery score was 3 (2 to 5).
The MAC of isoflurane in donkeys is similar to that reported in other species. Oxygen support should be provided to donkeys during recovery from isoflurane anesthesia to prevent hypoxemia. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-9645 1943-5681 |
DOI: | 10.2460/ajvr.21.12.0200 |