PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injury

Methods PET scans were performed with [11C]AFM on the HRRT scanner in 3 groups of animals: healthy control rats, rats injured with thoracic spinal cord contusions, and injured rats treated with the Nogo receptor fragment NgR(310)-ecto-Fc, which promotes axon regeneration [4]. Conclusion PET imaging...

Full description

Saved in:

Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Vol. 41; p. T154
Main Authors:	Huang, Yiyun, Nabulsi, N., Weinzimmer, D., Fung, E., Ropchan, J., Labaree, D., Wang, X., Gould, G., Frost, J.J., Carson, R.E., Strittmatter, S.M.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 2008 Elsevier Limited
Subjects:	Medical research Serotonin Spinal cord injuries
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Methods PET scans were performed with [11C]AFM on the HRRT scanner in 3 groups of animals: healthy control rats, rats injured with thoracic spinal cord contusions, and injured rats treated with the Nogo receptor fragment NgR(310)-ecto-Fc, which promotes axon regeneration [4]. Conclusion PET imaging of SERT in the spinal cord appears to be a promising biomarker for the initial loss of axon density after SCI and for axon re-growth in response to regeneration-promoting therapeutics.
ISSN:	1053-8119 1095-9572
DOI:	10.1016/j.neuroimage.2008.04.122