P03-08 Metabolism of Enniatin B in primary mouse, rat and human hepatocytes

Enniatins produced by Fusarium species belong to emerging mycotoxins commonly found in cereals and raising concern for food and feed. They are potentially toxic to humans and therefore represent a public health issue. However, due to the lack of toxicokinetic and toxicodynamic data that could be use...

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Bibliographic Details
Published in:	Toxicology letters Vol. 399; p. S125
Main Authors:	Dubreil, E., Ivanova, L., Gendre, C., Mahdjoub, M., Fessard, V., Le Hégarat, L., Faeste, C., Henri, J.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-09-2024 Elsevier
Subjects:	Life Sciences Toxicology toxicity sécurité alimentaire hepatocyte test in vivo toxicocinétique hépatocyte toxicologie enniantin céréale santé publique toxicodynamic toxicité Fusarium human humain public health cytotoxicity in-vitro test microsomes toxicology rat enniantine test in vitro in-vivo test cytotoxicité food safety mycotoxin toxicodynamique cereal toxicokinetic mycotoxine
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Summary:	Enniatins produced by Fusarium species belong to emerging mycotoxins commonly found in cereals and raising concern for food and feed. They are potentially toxic to humans and therefore represent a public health issue. However, due to the lack of toxicokinetic and toxicodynamic data that could be used to derive a Health-Based Guidance Value, enniatins are not regulated at the European level [1].
ISSN:	0378-4274 1879-3169
DOI:	10.1016/j.toxlet.2024.07.322