Influence of methylfenpropidine on growth, sterol content and fatty acid composition ofCandida albicans

• Published in: Folia microbiologica Vol. 45; no. 4; pp. 313 - 319
• Main Authors: Šajbidor, J., Breierová, E., Lamaćka, M., Bohov, P.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Nature B.V 01-08-2000
• Subjects: Composition; Dehydrogenation; Desaturase; Epoxidation; Fatty acid composition; Fatty acids; Fungicides; Isomerization; Linolenic acid; Lipids; Oleic acid; Reduction; Squalene; Zymosterol
• ISSN: 0015-5632; 1874-9356
• DOI: 10.1007/BF02817553

The effect of methylfenpropidine on growth, lipid contents, sterol and fatty acid composition was investigated in 5 strains ofCandida albicans. The sensitivity of the strains decreased in the order: wild strains >erg+ade nysR >ade nysRerg (defective Δ8−7-isomerase) >ade nysRerg (defective Δ5-desaturase). The presence of the inhibitor influenced fecosterol isomerization, episterol dehydrogenation, zymosterol transmethylation, ignosterol reduction and squalene epoxidation. Methylfenpropidine also induced changes in fatty acid composition, causing a reduction of the palmitic and oleic acid content with a concomitant elevation of stearic, linoleic and linolenic acid levels. The lipid unsaturation index slightly increased. Morphological changes of wild strains were observed after the fungicide treatment.