Cover Feature: Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity (Chem. Eur. J. 49/2021)

ESKAPE kit: A novel engineered cyclotide has effective broad‐spectrum antibacterial activity against several ESKAPE bacterial clinical isolates. The most active antibacterial cyclotide showed high in vivo efficacy against Pseudomonas aeruginosa, a human pathogen known to produce chronic lung infecti...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 27; no. 49; p. 12450
Main Authors:	Ganesan, Rajasekaran, Dughbaj, Mansour A., Ramirez, Lisa, Beringer, Steven, Aboye, Teshome L., Shekhtman, Alexander, Beringer, Paul M., Camarero, Julio A.
Format:	Journal Article
Language:	English
Published:	01-09-2021
Subjects:	broad-spectrum antibacterials cyclotides multidrug-resistant bacteria protegrins
Online Access:	Get full text
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Summary:	ESKAPE kit: A novel engineered cyclotide has effective broad‐spectrum antibacterial activity against several ESKAPE bacterial clinical isolates. The most active antibacterial cyclotide showed high in vivo efficacy against Pseudomonas aeruginosa, a human pathogen known to produce chronic lung infection in humans. These findings suggest the possibility of designing novel therapeutics based on the cyclotide scaffold. More information can be found in the Full Paper by J. A. Camarero et al. (DOI: 10.1002/chem.202101438).
Bibliography:	These authors contributed equally to this manuscript.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.202102541