Use of Pharmacogenetics To Optimize Asthma Therapy: Targeting The Glucocorticoid Receptor Gene

Use of Pharmacogenetics To Optimize Asthma Therapy: Targeting The Glucocorticoid Receptor Gene

The keywords used in the Medline search were ‘pharmacogenetics’,’glucocorticooids’ ‘glucocorticosteroids’ ‘glucocorticoid receptor’ ‘gene’ ‘gene variation’ ‘polymorphism’ with the subheading ‘asthma’ The main genetic pathways in glucocorticoid receptor gene affecting the response in asthma are consi...

Full description

Saved in:
Bibliographic Details
Published in:Clinical therapeutics Vol. 39; no. 8; p. e4
Main Authors: Fathallah, N., Chbili, C., Slim, R., Larif, S., Ben Salem, C.
Format: Journal Article
Language:English
Published: Bridgewater Elsevier Inc 01-08-2017
Elsevier Limited
Subjects:
Asthma
Glucocorticoids
Pharmacogenetics
Pharmacology
Polymorphism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The keywords used in the Medline search were ‘pharmacogenetics’,’glucocorticooids’ ‘glucocorticosteroids’ ‘glucocorticoid receptor’ ‘gene’ ‘gene variation’ ‘polymorphism’ with the subheading ‘asthma’ The main genetic pathways in glucocorticoid receptor gene affecting the response in asthma are considered. Discussion Although the glucocorticoid receptor is derived from a single gene (GR/NR3C1) belonging to the nuclear receptor superfamily including other receptors such as mineralocorticoids, sex steroids, thyroid hormones, vitamin D3 and retinoic acid ; several variants of GR proteins exist because of alternative splicing and alternative translation initiation mechanisms.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.07.027