Effect of ketorolac administration post bone cavitation surgery on some hematological parameters

• Published in: The Iraqi journal of veterinary medicine Vol. 41; no. 1; pp. 169 - 177
• Main Author: Umar, Rafal Abd al-Dayim
• Format: Journal Article
• Language: Arabic; English
• Published: Baghdad, Iraq University of Baghdad, College of Veterinary Medicine 05-06-2017
• Subjects: Ketorolac, Hematological parameters, Rabbits, Bone cavitation
• ISSN: 1609-5693; 2410-7409
• DOI: 10.30539/iraqijvm.v41i1.101

This study was designed to determine the effect of ketorolac on some hematological parameters
post cavitation surgery in domestic rabbits. Ninety-six adult domestic local breed male rabbits were
used in this study, weighing (1.23±0.33) kg. They were divided randomly into two groups in the
first one (n=48/group) represented control group, while the second one (n=48/group) represented
the treated group (Ketorolac group). All rabbits in both groups underwent surgical operation (bone
cavitation in femur bone) under general anesthesia. In the Ketorolac group, animals were treated by
using 30 mg/kg of Ketorolac directly post-operation and continued daily for 5 days, while in the
control group no treatment was given postoperatively. The hematological parameters were recorded
included white blood cells count; red blood cells count; hemoglobin; packed cell volume; mean
corpuscular hemoglobin and mean corpuscular hemoglobin concentration; mean corpuscular
volume and platelets at the period of (3, 5, 7, 14, 21, 28, 35, and 42) days post operation were
estimated. Results concerning hematological values showed no significant differences in packed
cell volume values between control and treated group and within each group, while haemoglobin
values showed a significant decrease at period 7 and 14 days between control and treated group.
Within the control group the significant decrease was noticed clearly at period of 7 days. Data
concerning mean corpuscular hemoglobin values within the control group showed a significant
decrease was noticed at 5 day, but within the treated group, there were no significant differences.
The mean corpuscular hemoglobin concentration values showed significant decrease ate period 3; 5
and 21 days between control group and treated group respectively. Within control group the
significant decrease was noticed obviously at 5 days while within treated group the significant
decrease was noticed at 35 days. The mean corpuscular volume values showed significant increase
at 3 and 5 days period between control and treated groups. Platelets counts within control group
showed significant increase at period of 14 days, within the treated group the significant increase
was recorded at 42 days. Red blood cells showed significant decrease between control and treated
groups, while within control group, the significant decrease was at 7 days. White blood cells count
within treated group showed significant increase recorded at 21 days. Differential White blood cells
count concerning Lymphocytes cells within control group the significant increase was recorded at
42 days while the significant decrease was noticed at 21 days, but within treated group the
significant increase were recorded at 35 days and significant decrease were noticed at 14 days.
Neutrophils counts showed significant decrease at periods 3, 14, 28 and 42 days between control
and treated groups respectively; while within the control group there was a significant decrease at 3
days, but within treated group the significant decrease was noticed at 42 days. Monocytes cells
showed a significant increase at 35 days between control and treated groups, within the control
group there was significant increase at 35 days, while within treated group the significant increase
recorded at 7 days.