Understanding zebrafish habituation responses to novelty

Though widely used to characterize animal cognitive phenotypes and their modulation, habituation phenotypes have not been extensively investigated in zebrafish (Danio rerio). Utilizing the novel tank test, we examined intra‐ and intersession habituation and demonstrated robust habituation responses...

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Bibliographic Details
Published in:	The FASEB journal Vol. 24; no. S1; p. 811.8
Main Authors:	Bartels, Brett, Tien, David, Wong, Keith, Tan, Julia, Cachat, Jonathan, Suciu, Chris, Goodspeed, Jason, Roy, Sudipta, Elegante, Marco, Elkhayat, Salem, Grimes, Chelsea, Rosenberg, Michael, Jackson, Andrew, Chung, Amanda, Gaikwad, Siddharth, Duncan, Ashley, Kadri, Ferdous, Stewart, Adam, Chung, Kyung Min, Strong, Michael, Gilder, Thomas, Zapolsky, Ivan, Kalueff, Allan V
Format:	Journal Article
Language:	English
Published:	Federation of American Societies for Experimental Biology 01-04-2010
Online Access:	Get full text
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Summary:	Though widely used to characterize animal cognitive phenotypes and their modulation, habituation phenotypes have not been extensively investigated in zebrafish (Danio rerio). Utilizing the novel tank test, we examined intra‐ and intersession habituation and demonstrated robust habituation responses in zebrafish. Intrasession habituation analysis determined that selected anxiogenic drugs (caffeine, pentylenetetrazol), as well as stress‐inducing alarm pheromone, attenuated habituation, while the acute anxiolytic agents, morphine and ethanol, had no effect on it. Chronic ethanol and chronic fluoxetine treatment attenuated intrasession habituation in zebrafish. Our study parallels rodent literature on habituation responses to novelty and reconfirms zebrafish as a promising model for cognitive neurobehavioral research. The study was supported by NARSAD, TUNF, TSEF, and TUIRF.
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fasebj.24.1_supplement.811.8