The use of1H-NMR spectroscopy for predicting the efficiency of neoadjuvant chemotherapy of breast cancer

The use of1H-NMR spectroscopy for predicting the efficiency of neoadjuvant chemotherapy of breast cancer

The pool of low-molecular-weight metabolites was studied in patients with breast cancer by high-resolution1H-NMR spectroscopy. In order to predict the efficiency of treatment, mathematical regression analysis was carried out with consideration for some clinical morphological characteristics of patie...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 130; no. 1; pp. 701 - 704
Main Authors: Semenova, N. A., Dydykina, I. Y., Dederer, L. Y., Tikhomirov, A. G., Gorbunova, V. A., Laktionova, K. P., Gorbacheva, L. B.
Format: Journal Article
Language:English
Published: New York Springer Nature B.V 01-07-2000
Subjects:
Breast cancer
Chemotherapy
Drug therapy
Magnetic resonance spectroscopy
NMR
Nuclear magnetic resonance
Patients
Physical characteristics
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Summary:The pool of low-molecular-weight metabolites was studied in patients with breast cancer by high-resolution1H-NMR spectroscopy. In order to predict the efficiency of treatment, mathematical regression analysis was carried out with consideration for some clinical morphological characteristics of patients, chemotherapy protocols, and the degree of therapeutic pathomorphosis. The efficiency of drug therapy was largely determined by metabolic status of tumors in untreated patients with breast cancer. [PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02682110