New preclinical models for neuro-oncology: Orthotopic patient-derived glioblastoma xenografts in mice

New preclinical models for neuro-oncology: Orthotopic patient-derived glioblastoma xenografts in mice

An abstract of the study conducted by Orthmann et al initiating the development of a preclinical models for neuro-oncology, orthotopic patient-dericed glioblastoma xenografts in mice is presented. The study found the histopathological analyses demonstrating glioma PDX models have retained the hetero...

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Bibliographic Details
Published in:European journal of cancer (1990) Vol. 69; p. S52
Main Authors: Orthmann, A, Haybäck, J, Jödicke, A, Kuhn, S, Linnebacher, M, Fichtner, I, Hoffmann, J
Format: Journal Article
Language:English
Published: Oxford Elsevier Science Ltd 01-12-2016
Subjects:
Animal models
Biomarkers
Brain cancer
Brain tumors
Drug development
Drug screening
Glioblastoma
Glioma
Hematology, Oncology and Palliative Medicine
Histology
Mice
Oncology
Patients
Research projects
Tumors
Xenografts
Xenotransplantation
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Summary:An abstract of the study conducted by Orthmann et al initiating the development of a preclinical models for neuro-oncology, orthotopic patient-dericed glioblastoma xenografts in mice is presented. The study found the histopathological analyses demonstrating glioma PDX models have retained the heterogeneity of the disease. Particularly the orthotopically transplanted glioma PDX are showing the original tumor histology and have better take rates in comparison to the s.c. engrafted tumors. The available panel of the broadly characterized 21 glioma PDX models provides an exceptional platform for translational oncology research projects, the identification and validation of new targets and biomarker candidates, screening of new drugs and combinations, as well as for personalizing patient treatment.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(16)32741-1