Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021)
In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS‐CoV‐2 viral spike and the ACE2‐bound spike complex. GO nanosheets were shown to inhibit the infection of wild‐type S...
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| Published in: | Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 25 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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24-06-2021
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| Abstract | In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS‐CoV‐2 viral spike and the ACE2‐bound spike complex. GO nanosheets were shown to inhibit the infection of wild‐type SARS‐CoV‐2 experimentally in cell cultures. Through an interplay of molecular dynamics simulations and cell biology, this work demonstrates that graphene oxide sheets could offer a platform to effectively interact and potentially transport other molecules to inactivate SARS‐CoV‐2. |
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| AbstractList | In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS‐CoV‐2 viral spike and the ACE2‐bound spike complex. GO nanosheets were shown to inhibit the infection of wild‐type SARS‐CoV‐2 experimentally in cell cultures. Through an interplay of molecular dynamics simulations and cell biology, this work demonstrates that graphene oxide sheets could offer a platform to effectively interact and potentially transport other molecules to inactivate SARS‐CoV‐2. |
| Author | Delogu, Lucia Gemma Akcali, Kamil Can Besbinar, Omur Kostarelos, Kostas Yalcin, Süleyman Suzuk Yildiz, Serap Alkaya, Damla Bayrakdar, Fatma Panatli, Oguzhan Fusco, Laura Nazir, Hasan Gurcan, Cansu Lozano, Neus Agan, Aydan Unal, Mehmet Altay Yilmazer, Açelya Arellano, Luis M. Celik, Dogantan |
| Author_xml | – sequence: 1 givenname: Mehmet Altay surname: Unal fullname: Unal, Mehmet Altay organization: Ankara University – sequence: 2 givenname: Fatma surname: Bayrakdar fullname: Bayrakdar, Fatma organization: Ministry of Health General Directorate of Public Health – sequence: 3 givenname: Hasan surname: Nazir fullname: Nazir, Hasan organization: Ankara University – sequence: 4 givenname: Omur surname: Besbinar fullname: Besbinar, Omur organization: Ankara University – sequence: 5 givenname: Cansu surname: Gurcan fullname: Gurcan, Cansu organization: Ankara University – sequence: 6 givenname: Neus surname: Lozano fullname: Lozano, Neus organization: UAB Campus Bellaterra – sequence: 7 givenname: Luis M. surname: Arellano fullname: Arellano, Luis M. organization: UAB Campus Bellaterra – sequence: 8 givenname: Süleyman surname: Yalcin fullname: Yalcin, Süleyman organization: Ministry of Health General Directorate of Public Health – sequence: 9 givenname: Oguzhan surname: Panatli fullname: Panatli, Oguzhan organization: Ankara University – sequence: 10 givenname: Dogantan surname: Celik fullname: Celik, Dogantan organization: Ankara University – sequence: 11 givenname: Damla surname: Alkaya fullname: Alkaya, Damla organization: Ankara University – sequence: 12 givenname: Aydan surname: Agan fullname: Agan, Aydan organization: Ankara University – sequence: 13 givenname: Laura surname: Fusco fullname: Fusco, Laura organization: University of Padua – sequence: 14 givenname: Serap surname: Suzuk Yildiz fullname: Suzuk Yildiz, Serap organization: Ministry of Health General Directorate of Public Health – sequence: 15 givenname: Lucia Gemma surname: Delogu fullname: Delogu, Lucia Gemma organization: University of Padua – sequence: 16 givenname: Kamil Can surname: Akcali fullname: Akcali, Kamil Can organization: Ankara University – sequence: 17 givenname: Kostas surname: Kostarelos fullname: Kostarelos, Kostas organization: The University of Manchester – sequence: 18 givenname: Açelya surname: Yilmazer fullname: Yilmazer, Açelya organization: Ankara University |
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| Snippet | In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular... |
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| SubjectTerms | antiviral therapeutics COVID‐19 in silico in vitro viral mutations |
| Title | Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021) |
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