Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021)

Antiviral Therapeutics: Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity (Small 25/2021)

In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS‐CoV‐2 viral spike and the ACE2‐bound spike complex. GO nanosheets were shown to inhibit the infection of wild‐type S...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 25
Main Authors: Unal, Mehmet Altay, Bayrakdar, Fatma, Nazir, Hasan, Besbinar, Omur, Gurcan, Cansu, Lozano, Neus, Arellano, Luis M., Yalcin, Süleyman, Panatli, Oguzhan, Celik, Dogantan, Alkaya, Damla, Agan, Aydan, Fusco, Laura, Suzuk Yildiz, Serap, Delogu, Lucia Gemma, Akcali, Kamil Can, Kostarelos, Kostas, Yilmazer, Açelya
Format: Journal Article
Language:English
Published: 24-06-2021
Subjects:
antiviral therapeutics
COVID‐19
in silico
in vitro
viral mutations
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Summary:In article number 2101483, Kostas Kostarelos, Açelya Yilmazer, and co‐workers report that thin, biological‐grade graphene oxide (GO) nanosheets show molecular affinity toward the SARS‐CoV‐2 viral spike and the ACE2‐bound spike complex. GO nanosheets were shown to inhibit the infection of wild‐type SARS‐CoV‐2 experimentally in cell cultures. Through an interplay of molecular dynamics simulations and cell biology, this work demonstrates that graphene oxide sheets could offer a platform to effectively interact and potentially transport other molecules to inactivate SARS‐CoV‐2.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202170123