Cover Picture: A Micropatterned Hydrogel Platform for Chemical Synthesis and Biological Analysis (Adv. Mater. 5/2006)

• Published in: Advanced materials (Weinheim) Vol. 18; no. 5
• Main Authors: Zourob, M., Gough, J. E., Ulijn, R. V.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 03-03-2006; WILEY‐VCH Verlag
• Subjects: Arrays; Biosensors; Cells; Enzymes; Hydrogels; Micropatterning; Peptides; Photolithography
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.200690022

A polymer hydrogel platform for peptide arrays compatible with both solid‐phase peptide synthesis conditions and the aqueous environment essential for biological assays is reported on p. 655 by Ulijn and co‐workers. Micropatterning followed by multiple‐step peptide synthesis produces the peptide‐functionalized poly(ethylene glycol)–polyamide “biochips” shown schematically on the cover. On‐chip biological assays involving cells and enzymes provide proof‐of‐concept.
A polymer hydrogel platform for peptide arrays compatible both with solid‐phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple‐step peptide synthesis in situ is followed by proof‐of‐concept on‐chip biological assays involving cells and enzymes (see Figure and cover).