Determination of osteocalcin, bone alkaline phosphatase, and lysyl oxidase in Iraqi acromegalic patients

• Published in: Ibn Al-Haitham Journal for Pure and Applied Sciences Vol. 31; no. 1; pp. 172 - 179
• Main Authors: Abbas, Iman A., Muhsin, Suhayb N., Abd, Bayda Ahmad
• Format: Journal Article
• Language: English
• Published: Baghdad, Iraq University of Baghdad, College of Education for Pure Science / Ibn al-Haitham 17-05-2018; University of Baghdad
• Subjects: Acromegaly, bone formation markers, osteocalcin, BALP, lysyl oxidase
• ISSN: 1609-4042; 2521-3407
• DOI: 10.30526/31.1.1864

This study was aimed to determine bone formation markers (OST and BALP) and lysyl
oxidase in diabetes and non-diabetes Iraqi acromegaly patients in addition to find the
relationship among these parameters. The present study conducted 60 acromegalic patients
(30 diabetes & 30 non diabetes) attending National Diabetes Center / AL-Mustansiriya
University/Baghdad, and 30 healthy individuals as a control group aged (35-60) years. All
patients were administrated Sandostatin drug, and they were diagnosed by physician in the
hospital.FBG, GH, IGF-1, OST, BALP, and LOX were determined in all groups. The results
showed a highly significant rise in all parameters (GH, IGF-1, FBG, OST, BALP, and LOX
values in serum of all patients when compared with normal individuals. There were some
positive highly significant correlations for lysyl oxidase with osteocalcin and a positive
significant with BALP in acromegalic patients. We concluded that lysyl oxidase may be a
novel biomarkers in endocrine diseases like acromegaly.