SPECIFIC FEATURES OF THE IMMUNE STATUS IN NEONATAL PNEUMONIA IN CHILDREN

• Published in: Zhurnal Grodnenskogo gosudarstvennogo medit͡s︡inskogo universiteta Vol. 16; no. 5; pp. 571 - 575
• Main Authors: Zhuravleva, L. N., Novikova, V. I.
• Format: Journal Article
• Language: Belarusian; English
• Published: Grodno State Medical University 01-11-2018
• Subjects: diagnosis; immune status; newborns; pneumonia; preterm newborn
• ISSN: 2221-8785; 2413-0109
• DOI: 10.25298/2221-8785-2018-16-5-571-575

Background. Pneumonia in newborns is a topical problem of pediatrics because of its significant morbidity, high disability. At present, there is no doubt that the immune system plays a leading role in the pathogenesis, clinical manifestations and outcome of respiratory diseases in newborns. The purpose of the study was to investigate immune status in newborn children with pneumonia. Material and methods. Immune status was studied in 20 healthy newborns and 32 children with neonatal pneumonia. Results. The state of immunity in newborn infants with infectious inflammatory diseases of the lung is characterized by an increase in the early precursors of T and B lymphocytes, immature T-lymphocytes and neutrophils, lack of mature immunocompetent cells (T and B lymphocytes, monocytes and neutrophils). Conclusions. In newborns with pneumonia there are significant changes in the immune system and factors of nonspecific protection, leading to secondary immune deficiency.