CuSO 4 -Catalyzed Tandem C(sp 3 )-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

CuSO 4 -Catalyzed Tandem C(sp 3 )-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles

A CuSO -catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of -aryl indoles from isonitriles.

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Bibliographic Details
Published in:Organic letters Vol. 22; no. 2; pp. 357 - 360
Main Authors: Shan, Xiang-Huan, Wang, Mei-Mei, Tie, Lin, Qu, Jian-Ping, Kang, Yan-Biao
Format: Journal Article
Language:English
Published: United States 17-01-2020
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Description
Summary:A CuSO -catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of -aryl indoles from isonitriles.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03751